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Gut Bacteria and Brain Chemistry: What’s the Connection?


You know that a healthy gut promotes proper digestion, but that’s not its only responsibility. It also encourages a boosted metabolism and thriving immune system. Additionally, your gut can even influence brain chemistry, according to Michael Gershon, professor and chair of pathology and cell biology at Columbia University.

“The gut can work independently of any control by the brain in your head – it’s functioning as a second brain,” Gershon told Psychology Today. “It’s another independent center of integrate neural activity.”

What’s the Connection?
So what makes this possible? Research from the University of Exeter Medical School and the University of Zaragoza in Spain found that the microorganisms in the gut may be regulating brain chemistry, according to Natural News.

There are 100 trillion bacteria and other microbes of different species living in the gut, often referred to as the gut microbiome. Some of those microbes located in the gut are marked by the protein TLR2, which helps regulate the chemical serotonin – a neurotransmitter that carries signals for the brain but also regulates bowel function. Through TLR2, the researchers believe that some of the gut microbes can impact serotonin levels, which ultimately influences your mood.

A healthy gut goes beyond good digestion.A healthy gut goes beyond good digestion.

Research published in the journal BioEssays also suggests that the microbiome in the gut have an impact on the food decisions we make through the vagus nerve, which connects from the digestive tract to the base of the brain. Athena Aktipis, a researcher involved in the study and student at the University of California San Francisco, shared how the microbiome affects more than digestion:

“Microbes have the capacity to manipulate behavior and mood through altering the neural signals in the vagus nerve, changing taste receptors, producing toxins to make us feel bad, and releasing chemical rewards to make us feel good,” she explained.

This means that by taking proper care of your gut, you’ll notice a positive shift in your mood and sense of taste. What’s the easiest way to ensure this happens? Eliminate the unhealthy foods that are difficult to digest from your diet and replace them with fresh and natural plant-sourced choices.

Fueling a Healthy Gut
Making healthier choices impacts your gut directly. When you fuel your body with mostly raw vegetables and other fiber-rich foods, your gut will react positively, digesting properly and promoting healthy immune and brain function. By following a primarily-raw, plant-based diet like the Hallelujah Diet, you can ensure your gut is fueled for success. Eat more fibrous foods like broccoli, turnip greens, Brussels sprouts, chia seeds and beets to reap the benefits.

Beyond a proper diet, you may consider a supplemental approach. Our Digestive Enzymes, Fiber Cleanse and Professional Strength Probiotics can balance health bacteria through the GI tract and eliminate harmful toxins from the body. If you’re ready to follow you gut instinct and promote a healthy system, shop our supplements today.


  1. Annette July 17, 2017

    This was a good blog to read about our gut. When I started to work here at HA I did not know how important the digestive enzymes was. Until one day I was listening to a customer telling me why she use it. She explain how she needed them with each meal. I was like wow. So I decided to buy me a bottle and I shared it with my husband and he started seeing great benefits from not having so much heartburn after meals. So this was more great information but since then I take the the probiotic. too. Some great supplements to help with the gut!

  2. Connie Gesser July 21, 2017

    Many experts in the field are teaching there is a direct connection between the brain and the gut. Eating a wide variety of fermented foods helps restore a lot of the beneficial bacteria which have been destroyed or bacteria that a person never had to start with. Wendy Jackson explains it well in the Hallelujah Diet webinar about making your own fermented foods.

  3. Jennifer July 16, 2019

    Thanks for this great article. It is very interesting how the gut and brain work together.

  4. CAROLYN B CALHOUN July 25, 2019

    The gut acts as a second brain. What a great observation. I know that once I started using Digestive enzymes I saw a great reduction in occurances of Heartburn. Excellent blog.

  5. This is a really interesting article I have decided to eat clean. This has transformed my life for the better. I came across this article that really helped me. Check it out …..bless everyone!

  6. justin grounds May 3, 2021

    I felt like a senior citizen at the age of 35! I was losing track of everything thinking I had developed some serious mental problem. Not to mention all the aches and pains I had all over my body some days I couldn’t bare getting out of bed. After 2 years of research and much anguish I came across an article about gut health and mental health. I read this testimony from a girl who was going through the same thing I was. I felt horrible for her, then I saw how good she was doing today. By changing her diet and repairing her gut biome. I didn’t have any other choice but to try it I was at the end. Today it’s like a new world has been opened up for me. If your struggling mentally or physically check your gut it might save your life! God bless

    • Melody Hord May 4, 2021

      Wow, Thanks justin!
      What all did you do to restore your GUT?

  7. Need help w stomach problems burgging

  8. Connie May 7, 2021

    Yes, I have also heard from other sources that bad bacteria in the gut can cause us to crave unhealthy food and overeat.
    But we do not have to give into those cravings. We can make good decisions about what kinds of foods we put into our body. We can monitor our food intake so we do not overeat.

  9. Angela May 12, 2021

    Interesting on how the gut and brain work together. Keep your gut healthy by eating the right foods and the Hallelujah Diet Digestive Enzymes and Professional Probiotics are great supplements to have each day to help achieve a healthy gut.

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